Relief

RSO during cancer treatment

Chemo and radiation are hard on the whole body. Here's what RSO can and cannot do, how patients use it alongside treatment, and how to do it safely with your care team.

Updated September 20267 min readBy the 2nd Star care team
Short answer

Can I use RSO during cancer treatment?

Many patients do. RSO (Rick Simpson Oil) is a concentrated full-spectrum cannabis oil taken by mouth, and during chemotherapy and radiation it is used to ease nausea, pain, poor sleep, appetite loss, and anxiety. It is not a cure for cancer and is not a substitute for treatment. Because it can interact with common medications, tell your oncology team before you start, use a lab-tested product, and start with a very small dose.

Treatment is supposed to make you better, and it usually does — but the road there can be brutal. Nausea that makes food impossible. Pain that doesn't answer to pills. Nights spent awake, wondering. If you're in the middle of that, this guide is for you. It's a plain-language look at how RSO fits into cancer care: what it actually helps with, what it doesn't do, and how to use it without getting in the way of the treatment that matters most.

First, the honest part
RSO does not cure cancer. You may have read stories online that say otherwise. There is no clinical evidence in people that RSO shrinks tumors or replaces chemotherapy, radiation, surgery, or immunotherapy. What it can do — and what thousands of patients use it for — is make treatment more bearable. Please never delay or stop a treatment your oncologist recommends in favor of RSO.

What treatment does to your body

Chemotherapy attacks fast-dividing cells — cancer cells, but also the lining of your stomach and mouth, your hair, and your bone marrow. Radiation inflames whatever it passes through. The result is the list most patients bring to us: nausea and vomiting, loss of appetite, pain (including chemo-induced nerve pain in the hands and feet), insomnia, and anxiety. Your oncology team has real tools for each of these, and you should use them. RSO is something many patients add on top, especially when standard anti-nausea drugs don't fully work.

What RSO is, briefly

RSO stands for Rick Simpson Oil — a thick, highly concentrated cannabis extract taken by mouth rather than smoked. It is full-spectrum, meaning it keeps the plant's natural mix of THC, CBD, and other compounds, which many believe work better together than alone. Because it's so concentrated, our tincture is dosed by the drop — a single drop is about 10 mg, and new users should dilute it further in plain MCT oil. For the full primer, read What is RSO?.

Cannabis for treatment side effects is not a fringe idea. The National Cancer Institute's clinician summary on cannabis and cannabinoids lists its potential benefits for people with cancer as anti-nausea effects, appetite stimulation, pain relief, and improved sleep — and notes that two THC-based prescription drugs, dronabinol and nabilone, are FDA-approved for chemotherapy side effects. The same summary is clear that the FDA has not approved cannabis to treat cancer itself.

What RSO can help with during treatment

Your body has a built-in network called the endocannabinoid system that helps regulate nausea, appetite, pain, sleep, and mood — almost exactly the list of things treatment disrupts. The compounds in RSO interact with that system. Here is what patients most often tell us it does for them:

What RSO cannot do

It cannot cure cancer. Laboratory and animal studies on cannabinoids and tumor cells are real but early, and the NCI notes that no clinical trials support cannabis as a cancer treatment in people. It cannot replace your treatment — patients who abandon proven therapy for cannabis oil lose time they may not get back. And it cannot fix everything at once: RSO builds gradually, sleep first, then appetite and nausea, then a steadier baseline over weeks.

Four rules for using RSO safely during treatment

1. Start low and go slow
Older online protocols call for massive doses — "60 grams in 90 days" is the famous one. Medical experts warn this can cause severe intoxication, anxiety, and side effects, on days you can least afford them. If you're new to cannabis, talk with a clinician and begin with a tiny fraction of a drop: 2.5–5 mg of THC, or a rice-grain-sized amount, at bedtime. Hold each dose several nights before increasing. Our full schedule is in RSO dosing: start low, go slow.
2. Check your medications
Cannabinoids are processed by the same liver enzymes as many prescription drugs and can interact dangerously with blood thinners like warfarin, certain antidepressants, and anti-rejection medications. Some chemotherapy drugs, anti-nausea medicines, sedatives, and opioids can also be affected, and drowsiness stacks. Bring the label to your pharmacist or oncologist and ask.
3. Insist on a tested product
Homemade extracts can contain dangerous residual solvents — alcohol, naphtha, or butane — along with mold or pesticides. That matters more when treatment has weakened your immune system. Lab-tested RSO from a licensed New Mexico source is the safer choice, and "Medical Grade" is what 2nd Star provides.
4. Always tell your oncologist
Speak openly with your cancer care team before introducing RSO or any cannabis product, so it doesn't conflict with your primary treatment plan. NCI's survey of 13,000 patients found a third used cannabis after diagnosis but only about one in five discussed it with their providers. Most oncology teams in New Mexico have this conversation regularly. Ask them to time doses around infusions, and share an oncology provider's guide if they want the clinical detail.

What to expect in the first weeks

The first few nights, expect better sleep and not much else. Over the next couple of weeks, as the dose eases upward, most patients notice mornings with less nausea and a little more interest in food. Pain relief usually follows. Treatment cycles will still have hard days; RSO tends to make them shorter and shallower rather than erase them. The patients who do best are the ones who go slow, keep their team informed, and treat RSO as one tool among several.

In New Mexico, yes: cannabis is legal for adults 21 and over and for registered medical patients, and RSO is available through licensed channels. For a family already facing treatment costs, the real barrier is price. Quality RSO is expensive month after month, and making it at home is dangerous. That gap is exactly why 2nd Star exists.

How to get RSO free during cancer treatment in New Mexico

2nd Star is a New Mexico community project founded by a cancer survivor who used RSO through her own treatment. We provide Medical Grade RSO — free of charge — to qualifying New Mexico patients living with cancer and other serious illness, and we pair every supply with clear dosing guidance. "Medical Grade" means it's produced to a consistent, tested standard, not improvised at home.

If you or a family member is in treatment, you can make a request through our short, confidential intake form. There's no cost, no insurance, and no catch — free medical cannabis, reviewed by a real person.

People also ask

Can I take RSO during chemotherapy?

Many patients do, to ease nausea, pain, poor sleep, and appetite loss during treatment. Because chemotherapy drugs and cannabis are both processed by the liver, tell your oncology team before you start so they can watch for interactions and adjust your care. Never stop or change a prescribed treatment to take RSO.

Does RSO cure cancer?

No. RSO is not a proven cure for cancer or any other disease. Claims online that it shrinks or eliminates tumors are not supported by clinical evidence in people. Patients use RSO for symptom relief alongside conventional treatment, not in place of it.

What does RSO help with during cancer treatment?

Patients most often use it for chemo-related nausea and vomiting, loss of appetite, pain (including nerve pain from chemotherapy), trouble sleeping, and anxiety. Many describe it as taking the edge off treatment so they can eat, rest, and get through the next round.

Can RSO interfere with chemo or radiation?

It can interact with medications, including blood thinners like warfarin, certain antidepressants, anti-rejection drugs, some chemotherapy agents, and sedatives, because they share the same liver enzymes. Radiation itself does not interact with cannabis, but the medications around it may. This is why your oncology team needs to know what you are taking.

How much RSO should a cancer patient take?

Start with a tiny fraction of a drop, about 2.5 to 5 mg of THC or a rice-grain-sized amount, at bedtime, and increase slowly over days and weeks. Older online protocols calling for 60 grams in 90 days can cause severe intoxication and anxiety; medical experts advise against them. A small nightly dose is often enough to sleep and wake with less nausea.

How can cancer patients get RSO for free in New Mexico?

2nd Star, a New Mexico community project, provides Medical Grade RSO at no cost to qualifying patients living with cancer and other serious illness. You can apply through the confidential intake form on this site. It is always free.

Treatment is hard enough

2nd Star provides Medical Grade RSO — free of charge — to New Mexico patients going through cancer treatment. Your request is private and reviewed by a real person.

Request free RSO

This guide is for education and is not medical advice. RSO is not a proven cure for cancer or any other disease. Always talk with your oncologist and care team before starting cannabis during treatment, especially if you take other medications.